To analyze the outcome of IKK2 inhibitor VIII (HY-13060, Medchem Express, Monmouth Junction, NJ) on OA improvement, MLI surgical procedures were executed in twelve-7 days-old C57BL/six WT mice. The mice were injected with IKK2 inhibitor VIII (two?mg/kg, IP) just about every alternate working day for 5 months. OARSI scoring was done by blinded revie